Adding some certain compound to certain chemical reactions, such as: 14062-24-9, name is Ethyl 4-chlorophenylacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14062-24-9. 14062-24-9
General procedure: Sodium hydride (60% in oil, 6.0g, 0.15mol) was added portionwise over a period of 15min to an ice-cold mixture of arylacetate (0.03mol) and ethyl formate (22.2g, 0.30mol) in dry Et2O (150mL). Once addition was complete, cooling bath was removed and the reaction mixture was left at room temperature for 12h and then carefully poured into cold water (200mL). The biphasic mixture was acidified with small portions of conc. aq. HCl until steady pH 2-3 was achieved. Layers were separated, organic phase was washed with brine, dried over Na2SO4 and concentrated under reduced pressure to dryness. Hydroxyacrylates 1a30 (yield 81%) and 1b30 (90%) were purified by distillation. Compounds 1c30 (70%) and 1d31 (75%) were washed by decantation with several small portions of cold petroleum ether. Characterization data are given in ESI.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 4-chlorophenylacetate.
Reference:
Article; Shestakov, Aleksandr N.; Pankova, Alena S.; Golubev, Pavel; Khlebnikov, Alexander F.; Kuznetsov, Mikhail A.; Tetrahedron; vol. 73; 27-28; (2017); p. 3939 – 3948;,
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