As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25662-28-6 name is Methyl 1-cyclopentene-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 25662-28-6
To a stirred solution of methyl cyclopent-1-enecarboxylate (2.0 g, 15.89 mmol) in DCM (15.0 mL) was added (benzyl((trimethylsilyl)methyl)amino) methyl methanesulfonate (4.0 mL, 15.88 mmol) at rt and the mixture stirred at 0 C. for 15 min followed by the drop wise addition of trifluoroacetic acid (0.50 mL). The mixture was then stirred for 16 h at rt. After completion of reaction (by TLC), solvent was evaporated, water added (50.0 mL) followed by extraction with EtOAc (3¡Á100 mL) and the combined organic layer washed with brine, dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure. The crude residue was purified over 100-200 M silica-gel using 7% EtOAc:hexane to obtain the product as a light yellow liquid (1.50 g, 75% yield). MS: 260.16 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1-cyclopentene-1-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; BIOTA EUROPE LTD.; US2012/88750; (2012); A1;,
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