140-11-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 140-11-4, name is Benzyl acetate, A new synthetic method of this compound is introduced below.
Into a column (Omnifit (registered trademark), inner diameter: 10 mm), 1.55 g (about 2.4 mL) of an anion exchange resin (DOWEX (registered trademark) 1¡Á2 100-200 Mesh, Cl form) was packed, and the column was placed in a column oven whose temperature was adjusted to 60 C., stood vertically and fixed. Next, 60 mL of 1 mol/L sodium methoxide solution previously prepared was fed into the column at a rate of 1.0 mL/min (SV: 25 hr-1) using a syringe pump (manufactured by YMC CO., LTD.). Next, 60 mL of methanol was fed into the column at a rate of 1.0 mL/min (SV: 25 hr-1) using a syringe pump to wash the resin. Subsequently, 34 g of methanol was added to 6 g of benzyl acetate to prepare a homogeneous solution, the prepared solution was passed through the column at a rate of 1.0 mL/min (SV: 25 hr-1) using a syringe pump, and the reaction solution was collected from an outlet of the column. As a result, the reaction solution containing 4.28 g of desired benzyl alcohol was obtained (yield: 99%). It was possible to selectively remove methyl acetate produced as a by-product by concentration operation. In the obtained reaction solution, only methyl acetate was identified, and no acetic acid was identified. Although the reaction rate gradually decreased due to a long-time feeding, the resin was regenerated by feeding a sodium methoxide solution to the column after use, whereby the reaction rate was recovered to the initial reaction rate.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KANEKA CORPORATION; MACHIDA, Koji; Yasukouchi, Hiroaki; Nishiyama, Akira; US2019/300465; (2019); A1;,
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