183322-16-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 183322-16-9 as follows.
1.6 Synthesis of ethyl 6-nitro-3,4-bis(methoxyethoxy)benzoateThe 0.23 mol ethyl 3,4-bis(methoxyethoxy)benzoate dissolved in 230 ml of acetic acid, maintaining the temperature of the systrem at 0-5C, 60 ml concentrated nitric acid was added. warmed to room temperature for 30 min, and continue reaction for 24h. The reaction mixture was poured into the 1000 ml water, ethyl acetate extraction (5¡Á250 ml), combined with the phase, are respectively using saturated NaHCO 3 solution (3x250mL) and saturated NaCl solution (3x250mL) washing, NaSO 4 drying. Activated carbon decolourizations, revolving off a solvent to obtain oil, yield 96%
According to the analysis of related databases, Ethyl 3,4-bis(2-methoxyethoxy)benzoate, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Normal University; Qi, Chuanmin; Wang, Xiao; Li, Shilei; He, Yong; Chen, Yurong; (16 pag.)CN103193722; (2016); B;,
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