Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5616-81-9, name is tert-Butyl 2-(methylamino)acetate, This compound has unique chemical properties. The synthetic route is as follows., 5616-81-9
Synthesis of (25,4a5,6a5,6bR, 8aR, 1OS,1 2a5, 1 2bR, 1 4bR)-Benzhydryl 1 O-(3 -((2-tert-butoxy-2- oxoethyl)(methyl)amino)-2-hydroxypropoxy)-2,4a,6a,6b,9,9, 1 2a-heptamethyl- 13 -oxo- 1,2,3 ,4,4a, 5,6,6a,6b,7,8,8a,9,1O,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate (95-1). A solution of 82-2 (40 mg, 0.058 mmol) and tert-butyl sarcosine (46 mg, 0.32 mmol) in THF (0.50 mL) and water (0.10 mL) was heated at 65C for 5 hours. The reaction was concentrated to drynessand purified by flash chromatography (4g 5i02, 0-5% MeOHIDCM) to give the title compound (47 mg).
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Reference:
Patent; ARDELYX, INC.; LUEHR, Gary; DRAGOLI, Dean; LEADBETTER, Michael; CHEN, Tao; LEWIS, Jason; (181 pag.)WO2019/60051; (2019); A1;,
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