Some common heterocyclic compound, 609-12-1, name is Ethyl 2-bromo-3-methylbutanoate, molecular formula is C7H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 609-12-1
General procedure: To a solution of sodium methoxide (prepared from 0.1mol of sodium in anhydrous MeOH (60mL)), 0.05mol of 1 and 0.055mol of ester (2a-h) were added and refluxed 1-3h (chromatographic control TLC). The solvent was evaporated and the residue was dissolved in water and neutralized with HCl to pH=7-8. The product was extracted with CHCl3, dried, concentrated, and crystallized from diethyl ether.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 609-12-1, its application will become more common.
Reference:
Article; Studzi?ska, Renata; Ko?odziejska, Renata; Kupczyk, Daria; P?azi?ski, Wojciech; Kosmalski, Tomasz; Bioorganic Chemistry; vol. 79; (2018); p. 115 – 121;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics