4224-69-5,Some common heterocyclic compound, 4224-69-5, name is Methyl 2-(bromomethyl)acrylate, molecular formula is C5H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred mixture of methyl 2-(bromomethyl)acrylate (239 mul, 2 mmol) in petroleum ether (3 ml) was added potassium carbonate (276 mg, 2 mmol), followed by sodium methoxide (119 mg, 2.2 mmol) and methanol (450 mul). The resulting mixture was stirred overnight, filtered, concentrated to a residue that was purified by column chromatography eluting with 10% ether in hexanes to provide the title compound (150 mg, 58%). (Reference: J. Med.Chem.; 42; 15; 1999; 2760-2773.)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(bromomethyl)acrylate, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2007/97937; (2007); A1;,
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