25597-16-4, A common heterocyclic compound, 25597-16-4, name is Ethyl 4,4,4-trifluorocrotonate, molecular formula is C6H7F3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The resulting product (0.45g, 1.9mmol) from step 4, ethyl 4,4,4-trifluorocrotonate (1.3g, 7.6mmol) and anhydrous potassium carbonate (2.6g, 1.9mmol) were dissolved in DMF (10mL), and then the system was stirred for 2hrs at 90C. At the end of reaction, the reaction system was cooled to room temperature and added with water, the mixture was extracted with ethyl acetate, and the organic phase was dried and evaporated in vacuum to obtain 0.40g of the product (55%) by column chromatography. 1HNMR (400 MHz, d-CDCl3), delta 7.88(s, 1H), 6.76 (s, 1H), 5.7(m, 1H), 4.3(dd, 2H),1.35(t, 3H) MS (MM-ES+APCI), m/z: 384 (M-H+)
The synthetic route of 25597-16-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences; ZHANG, Yanmei; TALLEY, John Jeffrey; OBUKOWICZ, Mark G.; TU, Zhengchao; TORTORELLA, Micky; WANG, Yican; LIU, Jianqi; CHEN, Yan; LIU, Xiaorong; LU, Xin; EP2845854; (2015); A1;,
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