4131-74-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4131-74-2 as follows.
26.16g (0.1411 mol) of octadecylamine was added to a 250 ml reaction flask, followed by addition of 100ml of high-boiling petroleum ether (90-120 C) or toluene or ethanol, 1-10% (molar ratio) of p-toluenesulfonic acid or hydrochloric acid or acetic acid or hydrochloric acid and 10g (0.04848 mol) of intermediate of product V. Placed in a constant temperature oil bath pot and stirred the reaction temperature was set at 125 , nitrogen protection plus condensate trap. (Time to complete the reaction time is about 36-48 hours, with increasing temperature the reaction flask to dissolve the solid into a liquid, when the end of the reaction, the flask was cooled to room temperature, the liquid into a solid whole. To the reaction flask with stirring adding an appropriate amount of methanol, and then subjected to suction filtration, washed with methanol 2-4 times, after heating to 40 degrees Celsius drained and dried under vacuum to give a white solid, yield 86-97%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4131-74-2, and friends who are interested can also refer to it.
Reference:
Patent; Shaoxing Ruikang Biotechnologies Co., Inc.; Mao, Lijuan; Liu, Shubai; Wang, Songping; Zhang, Zaixian; Wan, Dingfei; Peng, Chuanyang; Ding, Yifan; Sun, Xing; (21 pag.)CN105693545; (2016); A;,
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