3196-15-4, Name is Methyl 2-bromobutyrate, 3196-15-4, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Example 1. Synthesis of benzo bis-furan compound IV-1 (1) In a round-bottom flask equiped with a reflux condenser and a magnetic stirrer, 0.5135g (1.0mmol) of compound I dissolved in 10mL DMF and 0.346g (2.5mmol) potassium carbonate was added. The reaction was stirred at room temperature. After ten minutes, 0.272g (1.5mmol) 2-bromobutyric acid methyl ester VI-a-1 was added and stirring was continued for 5h. After completion of the reaction, 30mL of dichloromethane was added with copious amount of water (80mL¡Á5) until removal of DMF. The organic phase was seperated, dried over anhydrous magnesium sulfate, concentrated, and purified by TLC (E/P [ethyl acetate:petroleum ether] = 1:5) to give the benzofuran II-a-1. Yield 75%
Statistics shows that Methyl 2-bromobutyrate is playing an increasingly important role. we look forward to future research findings about 3196-15-4.
Reference:
Patent; Zhejiang University; Wang, Yuguang; Zhu, Bingchun; Liu, Juanfang; Li, Qingsi; (14 pag.)CN104016998; (2016); B;,
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