178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 178312-47-5
To a reaction mixture of 4,4-difluorocyclohexanecarboxylic acid ethyl ester (7.1 g, 37 mmol) in THF (50 mL) cooled to 0 C. was added dropwise 2.0 M lithium tetrahydroaluminate in THF (18.5 mL) over 10 min. The reaction mixture was stirred at 0 C. for 1 h. Water (5 mL) was added dropwise, followed by 1.0N NaOH (5 mL). The reaction mixture was filtered through Celite, THF was evaporated, and the resulting aqueous solution was diluted with brine (50 mL) and extracted with ethyl acetate (50 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and concentrated to give the title compound as a clear oil (5.6 g) which was used without further purification.
Statistics shows that 178312-47-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 4,4-difluorocyclohexanecarboxylate.
Reference:
Patent; Saito, Daisuke Roland; Long, Daniel D.; Van Dyke, Priscilla; Church, Timothy J.; Jlang, Lan; Frieman, Bryan; US2009/62333; (2009); A1;,
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