89-91-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89-91-8, name is Methyl 2,2-dimethoxyacetate, A new synthetic method of this compound is introduced below.
Step 1 : Preparation of 1-(2,4-dichloropyridin-3-yl)-2,2-dimethoxyethan-1-one . A cold (-78 C) solution of 2,4-dichloro-3-iodopyridine (2.73 g, 9.968 mmol) in THF (49.84 mL) was treated dropwise with 2.5 M n-BuLi in hexanes (4.785 mL, 11.96 mmol). After stirring for 20 min at -78 C, the reaction mixture was treated dropwise with methyl 2,2-dimethoxyacetate (1.708 mL, 13.95 mmol). The resulting mixture was stirred for 1 h at -78 C, before quenching with saturated NH4Cl(aq) (10 mL). The quenched mixture was allowed to warm to ambient temperature. Subsequently, the mixture was diluted with water (30 mL), and extracted with EtOAc. The organic extracts were dried over anhydrous Na2S04(S>, filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography (0-30% EtOAc in hexanes) to afford the title compound (1.9 g, 76%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARRAY BIOPHARMA INC.; WALLS, Shane M.; REN, Li; RAMANN, Ginelle A.; MORENO, David A.; METCALF, Andrew T.; MCFADDIN, Elizabeth A.; KOLAKOWSKI, Gabrielle R.; BLAKE, James F.; DAI, Donghua; HAAS, Julia; JIANG, Yutong; KAHN, Dean; (368 pag.)WO2019/143994; (2019); A1;,
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