In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 701-83-7 as follows. 701-83-7
To 122 g (0.79 mol) of 3-fluorophenylacetate was added Aids (137 g, 1.03 mol) and theresulting mixture was heated at 160 C for 1.5 h then cooled at 0 C. HC1 IN was carefully addedfollowed by Et2O. The aqueous phase was extracted(2X) with Et2O and the combined organic phasewashed with brine, dried over Na2SO4 and evaporated to give the title compound.
According to the analysis of related databases, 701-83-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK FROSST CANADA & CO.; WO2004/108720; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics