58101-60-3, The chemical industry reduces the impact on the environment during synthesis 58101-60-3, name is Methyl 3-cyclopentenecarboxylate, I believe this compound will play a more active role in future production and life.
EXAMPLE 39 (+-) Methyl 3-Butyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-5-carboxylate (45, Scheme 9, Ester Group and Isooxazoline Ring are cis to Each Other), and (+-) Methyl 3-Butyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-5-carboxylate. (46, Scheme 9, Ester Group and Isooxazoline Ring are trans to Each Other) To a refluxing solution of methyl 3-cyclopenten-1-carboxylate 43 (10.21 g, 80.9 mmol) and phenyl isocyanate (17.5 mL, 161 mmol) in dry benzene (50 mL) was added dropwise, a mixture of 1-nitropentane (10.8 mL, 87.8 mmol) and Et3N (20 drops) in dry benzene (30 mL) over a period of 1 h. The mixture was heated at reflux for an additional hour. The solids were removed by filtration, and washed with Et2O. The combined filtrate was concentrated to yield orange oil, which was purified by flash chromatography (silica gel, 0 to 50% ethyl acetate in hexanes).
The chemical industry reduces the impact on the environment during synthesis Methyl 3-cyclopentenecarboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BioCryst Pharmaceuticals, Inc.; US6562861; (2003); B1;,
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