The important role of 3469-00-9

3469-00-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-00-9, name is Methyl Diphenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 13: Preparation of 3-(S) – methyl- 2,2- diphenyl-2 -( 1-tosyl pyrrolidin -3- yl) acetate:2,2-diphenyl acetic acid methyl ester (22.6 grams) was added to a stirred suspension of sodium hydride (4 grams of a 60% suspension in oil) in anhydrous toluene (250 ml). The mixture was heated to 55-600C and stirred for 1 hour. The reaction mixture was cooled to 25-300C and 3-(S)-I -tosyl-3-tosyloxypyrrolidine (39.5 grams) was added to the above mixture in portions and the mixture was heated to reflux temperature. The reaction mixture was stirred for 3 hours at reflux temperature. The reaction mixture was cooled to 25-30C and quenched with methanol. The organic layer was washed with 5% aqueous sodium hydroxide then dried with sodium sulphate. Distilled off the toluene under reduced pressure to get solid. The obtained solid was purified by using ethyl acetate to give title compound as crystalline solid.Yield: 25 grams; M.R: 183-186C

The synthetic route of Methyl Diphenylacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
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