In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23786-14-3 as follows. 23786-14-3
Methyl bromo(4-methoxyphenyl)acetate; A mixture of 13.4 g (74.4 mmol) of methyl (4-methoxyphenyl)acetate, 13.9 g (78.1 mmol) of Lambda/-bromosuccinimide and a catalytic amount of AIBN in tetrachloromethane (120 ml) was heated under reflux with stirring for 2 h. The cooled reaction solution was filtered and the solvent was removed in vacuo. Yield: 18.98 g (98%) of yellow oil1H-NMR (CDCI3): 3.78 (s, 3H), 3.81 (s, 3H), 5.35 (s, 1 H), 6.88 (d, 8.7 Hz, 2H), 7.48(d. 8.7 Hz, 2H).MS (API-ES,pos) m/z = 179 [M+H-Br]+
According to the analysis of related databases, 23786-14-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
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