In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6065-82-3 as follows. 6065-82-3
(i) 2,2-Diethoxyacetamide(See, for example, Inami, K., Shiba, T., Bull. Chem. Soc. Jpn., 1985, 58, 352.) Ethyl diethoxyacetate (Aldrich) (10 mL, 56.41 mmol) was added to concentratedNH4OH (50 mL) and the mixture allowed to stir until a homogeneous solution was obtained (40 hours). The solvent was then removed under reduced pressure to yield the sub-title compound as fine white needles (8.209 g, 99%). m.p. = 47-51C. vmax KBr/cm”1: 3495, 3298 upsilon(N-H), 2898 upsilon(C-H), upsilon(N-Me) 1673 upsilon(C=O), 1317 delta(C-O). deltaH 1H(CDCl3): 1.11 (6H, t, 2(CH3) (J=8.0Hz)), 4.55 (4H, m, 2(CH2)), 4.64 (IH, s,C-H), 7.25 (2H, d, NH2 (J=I 88.0Hz)).LREIMS: Found 148.00 (M+H) calculated for C6Hi3NO3 147.09.
According to the analysis of related databases, 6065-82-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF STRATHCLYDE; WO2008/38018; (2008); A1;,
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