Share a compound : 178312-47-5

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 4,4-difluorocyclohexanecarboxylate.

Adding some certain compound to certain chemical reactions, such as: 178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 178312-47-5. 178312-47-5

Example 1 : 4,4-Difluorocyclohexanecarboxamide; A suspension of ethyl 4,4-difluorocyclohexanecarboxylate (2500mg, 13mmol) in ammonium hydroxide (28%, 50 ml) was stirred at 60 C overnight. After removal of solvent, the residue was washed with water. The precipitate was obtained as product (white solid, 800 mg). 1H NMR (300 MHz, CDCl3): delta 5.31-5.45 (br, 2H), 2.02-2.27 (m, 3H), 1.92-2.02 (m, 2H), 1.72- EPO 1.87 (m, 4H). The mother liquor was acidified with IN HCl to pHPatent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/21309; (2007); A1;,
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