Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-91-8, name is Methyl 2,2-dimethoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., 89-91-8
General procedure: To a solution of diisopropylamine (1.5 eq.) in THF (1.5M) at ooc under N2 was added nBuli(1.4eq., 1.6M in hexane) and the mixture was stirred for 20 min. The LOA was cooled to -80C20 and TMSCI (1.4 eq.) was added followed by the methyl ester (1 eq.). The reaction was allowedto reach ooc over 3 h, brought to rt and stirred for 30 min. Pentane was added and the whiteprecipitate filtered off over celite. The solvent was removed under reduced pressure. Purificationif necessary was performed by bulb-to-bulb distillation.
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Reference:
Patent; SANDOZ AG; HOEFERL-PRANTZ, Kathrin; FELZMANN, Wolfgang; WILHELM, Thorsten; BENITO-GARAGORRI, David; WO2013/189980; (2013); A1;,
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