2555-28-4, A common heterocyclic compound, 2555-28-4, name is 7-Methoxy-4-methylcoumarin, molecular formula is C11H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of compound 22b (1.0 g, 5.3 mmol), NBS (1.4 g, 7.9 mmol) and BPO (20 mg) in CHCl3(30 mL) was heated to reflux at 70C for 8 hours. The reaction mixture was cooled to 0C, diluted with water, and extracted with CHCl3. The organic phase was concentrated in vacuo to afford compound 22c (1.0 g, 71 %).
The synthetic route of 2555-28-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KOZLOWSKI, Joseph; COBURN, Craig; YU, Wensheng; TONG, Ling; HU, Bin; ZHONG, Bin; HAO, Jinglai; WANG, Dahai; JI, Tao; WO2015/89810; (2015); A1;,
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