Share a compound : 3196-15-4

Statistics shows that 3196-15-4 is playing an increasingly important role. we look forward to future research findings about Methyl 2-bromobutyrate.

3196-15-4, name is Methyl 2-bromobutyrate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3196-15-4

1.80 g (9.66 mmol) of tert-butyl 2-(aminomethyl)azetidine-1-carboxylate [racemate] were dissolved in 25 ml of dichloromethane, 1.62 ml (1.17 g, 11.6 mmol) of triethylamine and 1.11 ml (1.75 g, 9.66 mmol) of methyl 2-bromobutanoate [racemate] were added and the mixture was stirred under reflux overnight. 1.35 ml (0.98 g, 9.66 mmol) of triethylamine and 0.89 ml (1.40 g, 7.73 mmol) of methyl 2-bromobutanoate [racemate] were then added, and the mixture was stirred under reflux overnight. After cooling to room temperature, water was added and the phases were separated. The aqueous phase was extracted twice with dichloromethane and the combined organic phases were washed with saturated aqueous sodium chloride solution, dried over sodium sulphate, filtered and then freed of the solvent under reduced pressure. This gave 2.64 g (83% of theory, purity: 87%) of the desired product. LC-MS (Method 6A): Rt=2.16 min (diastereomer 1, 2 isomers), Rt=2.22 min (diastereomer 2, 2 isomers); MS (ESIpos): m/z=287 [M+H]+

Statistics shows that 3196-15-4 is playing an increasingly important role. we look forward to future research findings about Methyl 2-bromobutyrate.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ALLERHEILlGEN, Swen; BUCHMUeLLER, Anja; ENGEL, Karen; GERDES, Christoph; GERICKE, Kersten Matthias; GERISCH, Michael; HEITMEIER, Stefan; HILLlSCH, Alexander; KINZEL, Tom; LIENAU, Philip; RIEDL, Bernd; ROeHRIG, Susanne; SCHMIDT, Martina Victoria; STRASSBURGER, Julia; TERSTEEGEN, Adrian; (135 pag.)US2016/108027; (2016); A1;,
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