Adding some certain compound to certain chemical reactions, such as: 455-68-5, name is Methyl 3-fluorobenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-68-5. 455-68-5
REFERENCE EXAMPLE 68 Dimethyl 2-m-fluorophenyl-2-oxoethylphosphonate (68) STR87 To a stirred solution of dimethyl methylphosphonate (10.1 g, 81.2 mmol) in 100 ml of anhydrous THF was added dropwise n-butyl lithium (1.58N, 51.4 ml, 81.2 mmol) at -78¡ã C. under argon atmosphere. After 30 minutes, methyl m-fluorobenzoate (5.0 g, 32 mmol) was further added dropwise and the mixture was stirred for 30 minutes. The reaction solution was allowed to warm to 0¡ã C., diluted with 4.9 ml of acetic acid and 10 ml of water, and concentrated. 30 ml of water was added to the residue and the mixture was extracted with ethyl acetate (50 ml*2). The combined ethyl acetate layers were washed with water (20 ml*1) and brine (20 ml*1), dried over anhydrous sodium sulfate, and concentrated. The residue was distilled under reduced pressure to give an oil of dimethyl 2-m-fluorophenyl-2-oxo-ethylphosphonate (6.6 g, 26.8 mmol, yield 83.8percent, b.p. 132¡ã-134¡ã C./0.17 mmHg), which was assigned the structure by the following data: IR(Liquid film method): 3450, 3060, 2940, 2840, 1680, 1580, 1475, 1430, 1400, 1290, 1260, 1190, 1110, 1055, 1030, 870, 825, 790, 760, 710, 665 cm-1. NMR (90 MHz, CDCl3, delta): 3.62(2H, d, J=22.6 Hz), 3.79(6H, d, J=11.4 Hz), 7.15-7.9(4H, m).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl 3-fluorobenzoate.
Reference:
Patent; Toray Industries, Inc.; US4775692; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics