Brief introduction of 89-91-8

The synthetic route of 89-91-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-91-8, name is Methyl 2,2-dimethoxyacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 89-91-8

Method 1; Ethyl 4,4-dimethoxy-3 -oxobutanoate; To a solution of dimethoxy methyl acetate (25 g, 0.19 mol) in EtOAc (75 ml), was added sodium hydride (8.5 g, 0.21 mol) in portions. After all the sodium hydride was added, the mixture was set to reflux for 10 hours. The reaction mixture was poured onto cold water followed by pH adjustment to 3-4 using 3N HC1 solution. The layers were separated and the organic layer was dried, filtered, and concentrated in vacuo to afford 34 g (96% crude recovery) of the title compound, which was used further without purification.

The synthetic route of 89-91-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/8523; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics