63106-93-4, name is 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 63106-93-4
Diethylamine (1 .56 g, 21 .3 mmol) is added dropwise to a suspension of aluminum trichloride (1 .38 g, 10.4 mmol) in toluene (9.6 mL), cooled to 0 C under magnetic stirring and in nitrogen atmosphere, checking that the internal temperature of the system does not exceed 15 C. The obtained solution is maintained at 25 C for about 30 minutes, then a toluene (2 mL) solution of lactone A (1 .50 g, 8.6 mmol) is slowly added. The mixture is maintained under magnetic stirring at 25 C up to complete conversion (about 2 hours), then poured into water (7.2 mL) previously cooled to 5 C, checking that the internal temperature does not exceed 25 C. The obtained phases are separated and the aqueous phase extracted with toluene. The organic phase is filtered on a panel of activated carbon and celite, and concentrated at reduced pressure until a residue of 2.50 g (containing about 2.10 g of the desired product) is obtained, which is used in the next step without any further purification.
Statistics shows that 63106-93-4 is playing an increasingly important role. we look forward to future research findings about 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one.
Reference:
Patent; QUIMICA SINTETICA, S.A.; BARRECA, Giuseppe; ROMANO’, Bruno Gaetano; (16 pag.)WO2016/71303; (2016); A1;,
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