The important role of 42726-73-8

Statistics shows that tert-Butyl methyl malonate is playing an increasingly important role. we look forward to future research findings about 42726-73-8.

42726-73-8, Name is tert-Butyl methyl malonate, 42726-73-8, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Potassium hydroxide (2.00 g, 36.0 mmol), tert-butyl methyl malonate (1.22 mL, 7.2 mmol) and DCM (20 mL) were added to a 100-mL flask under inert atmosphere. The mixture was stirred at room temperature until the solution became white then PhI(OAc)2 (1.93 g, 6.0 mmol) was added and stirred at room temperature for 2 hours. The solution was filtered through a cotton plug and washed with small portions of DCM. The solvent was removed under reduced pressure and the remaining oil was placed under high vacuum for 2 hours. The oil crystallized and the resulting solid was used without further purification. 1.038 g (46percent); off-white solid; m.p. 95-97¡ãC (dec.); 1H NMR (CDCl3; 600 MHz): delta 1.45 (s, 9H), 3.77 (s, 3H), 7.40-7.43 (m, 2H), 7.52-7.54 (m, 1H), 7.71-7.73 (m, 2H); 13C NMR (CDCl3; 150 MHz): delta 28.6, 52.5, 80.1, 114.5, 127.5, 130.3, 131.3, 131.5, 163.9, 164.4; HRMS: Calculated for C14H18IO4 (377.0250) [M+H]+, Found: 377.0255.

Statistics shows that tert-Butyl methyl malonate is playing an increasingly important role. we look forward to future research findings about 42726-73-8.

Reference:
Article; Stokes, Sean; Mustain, Rachel; Pickle, Lydia; Mead, Keith T.; Tetrahedron Letters; vol. 53; 30; (2012); p. 3890 – 3893;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics